DO THIS MISSION AS SOON AS YOU RECEIVE IT!
There are two main reasons for this. First, you get a new squadmate after completing this mission, which is always a good thing. Second, and just as important, completing this mission once you get it (if you have it installed before playing the game, it will be right after your first visit to the Citadel) ensures that no other missions will be "locked out" by going after this mission first.
Liara is a mandatory squadmate for this mission, but that's a good thing. Her biotic powers, especially Singularity, can help tremendously against some of the tougher enemies in this mission, rendering them helpess for easy shots. If you are doing this mission immediately after getting it, you will have James as your other squadmate, meaning you will have a high-damage tank and a great biotic backing you up, which is a potent combination.
There are a lot of enemies for such a small mission, so use cover, even on lower difficulties, so that you are not overwhelmed.
This will likely be your first time going up against certain types of Cerberus troopers, namely Combat Engineers, the Nemesis and the Atlas Mech. You'll also face some Guardians as well. Some things to keep in mind:
1. Always take cover when the Nemesis's sniper rifle laser sight is up, as these weapons pack a powerful punch on any difficulty.
2. Try to take down Engineers BEFORE they can spawn their Turrets. If they are left unchecked, their Turrets can take you down quick. Use any powers you have available (ex. Concussive Shot, Liara's Singularity, James's Carnage) to defeat them before their Turrets can go online. Keep in mind that there will be times when you will deal with Turrets already online. Your best move is to TAKE COVER and take them out first.
3. There is a point later in the mission where you will face Guardians, Engineers and Turrets all at once. Take cover and use your powers wisely (Singularity is your best move, especially with an upgrade to its radius) and you'll make it through without a problem.
4. This is likely your easiest chance to hijack an Atlas Mech (and earn the Hijacker
trophy), since the Atlas Mech is supported only by regular Assault Troopers. Whether you hijack it or not, remember to stay in cover and heed Liara's advice of not letting it get too close.
Speaking of trophies from the "core game", this is a good mission to work towards Mail Slot
and even Combined Arms
, so long as it is not done at the expense of completing the mission.