To use the in-game tweaks you have to first complete the story once, and then you are allowed to use the tweaks on that difficulty and lower. If you were to, for example, complete the game on Hard and try to use the tweaks on Crushing it wouldn't work, though there is a way around that I won't mention which allows you to do that. There's little point in me looking up the way as I've already 'd UC2.
__________________________________________________ Building my first Desktop PC in January!
Windows 7 Ultimate 64-bit / G-Skill RipJaws X 16GB DDR3-1600mhz RAM / Seagate 2TB 7200RPM HDD / ASUS ASRock Z77 / Intel Core i5-3350P / AMD R9 270X / Fractal Design R4 / Corsair AX750W 80+ Gold / LG CH12LS28 12x SATA Optical Drive / Razor (Blue) DeathAdder 6400 DPI / Microsoft Sidewinder X4
Valued at only $990 - subject to possible changes...
I wish these games [Uncharted 2 and 3] gave more reason to play the stellar online modes, other than severe amounts of DLC trophies. Only needing 2 Online related trophies to plat kind of gives no real reason to need to play online, kind of sad. Then again, needing to spend $30+ on DLC for UC3 seems a bit intense, as well. [Unless of course you got the GOTY edition - I only just got the PS+ edition which is a rip off lol]