Red Dead Redemption! Though there's still a lot of big name games I have yet to play.
PLATINUMS: 3D Dot Game Heroes, Batman: Arkham Asylum, Assassins Creed 2, Bioshock, Borderlands, Brutal Legend, Burnout Paradise, Call of Duty: World at War, Call Of Duty: Modern Warfare 2, Darksiders, Dragon Age: Origins, Dragon Age 2, Enslaved: Oddysey of the West, Final Fantasy XIII, God Of War I & II, Madden 10,11 & 12, Shaun White Snowboarding, Sonic's Ultimate Genesis Collection, Uncharted: Drake's Fortune, Uncharted 2: Among Thieves
I'll probably be the only one saying this but Twisted Metal. Too bad the online has been dead forever.
Not this anymore but the best game is Terminator Salvation. I mean epic storyline, amazing controls, revolutionary gameplay, great voice acting. Lots of people really like the game so it should win game of this generation but I hear Leisure Suit Larry Box Office Bust is also an amazing game but never played it so can't say which is better.