Brass Balls
Complete the game on Hard difficulty without using a Vita-Chamber
“Worlds of Hurt” – Tough Guy
Rescued the Little Sister in “Worlds of Hurt” using only plasmids, tonics, the wrench, and the research camera, on Medium or higher difficulty
Ammo Inventor
The player has successfully invented all possible ammo types
Bought One Slot
The player has purchased one slot in any Plasmid or Tonic track
Irony
The player has taken a picture of Sander Cohen's corpse
Maxed One Track
The player has purchased every slot in one of the Plasmid or Tonic tracks
Tonic Collector
Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks